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Title:

Full-length L1CAM and not its ?2?27 splice variant promotes metastasis through induction of gelatinase expression.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hauser, S; Bickel, L; Weinspach, D; Gerg, M; Schäfer, MK; Pfeifer, M; Hazin, J; Schelter, F; Weidle, UH; Ramser, J; Volkmann, J; Meindl, A; Schmitt, M; Schrötzlmair, F; Altevogt, P; Kruger, A
Abstract:
Tumour-specific splicing is known to contribute to cancer progression. In the case of the L1 cell adhesion molecule (L1CAM), which is expressed in many human tumours and often linked to bad prognosis, alternative splicing results in a full-length form (FL-L1CAM) and a splice variant lacking exons 2 and 27 (SV-L1CAM). It has not been elucidated so far whether SV-L1CAM, classically considered as tumour-associated, or whether FL-L1CAM is the metastasis-promoting isoform. Here, we show that both var...     »
Journal title abbreviation:
PLoS ONE
Year:
2011
Journal volume:
6
Journal issue:
4
Pages contribution:
e18989
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0018989
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21541352
Print-ISSN:
1932-6203
TUM Institution:
Frauenklinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung
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