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Titel:

Using magnetic forces to enhance non-viral gene transfer to airway epithelium in vivo.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Xenariou, S; Griesenbach, U; Ferrari, S; Dean, P; Scheule, RK; Cheng, SH; Geddes, DM; Plank, C; Alton, EW
Abstract:
We have assessed whether magnetic forces (magnetofection) can enhance non-viral gene transfer to the airways. TransMAG(PEI), a superparamagnetic particle was coupled to Lipofectamine 2000 or cationic lipid 67 (GL67)/plasmid DNA (pDNA) liposome complexes. In vitro transfection with these formulations resulted in approximately 300- and 30-fold increase in reporter gene expression, respectively, after exposure to a magnetic field, but only at suboptimal pDNA concentrations. Because GL67 has been fo...     »
Zeitschriftentitel:
Gene Ther
Jahr:
2006
Band / Volume:
13
Heft / Issue:
21
Seitenangaben Beitrag:
1545-52
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.gt.3302803
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16738690
Print-ISSN:
0969-7128
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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