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Title:

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Vasiljeva, O; Papazoglou, A; Kruger, A; Brodoefel, H; Korovin, M; Deussing, J; Augustin, N; Nielsen, BS; Almholt, K; Bogyo, M; Peters, C; Reinheckel, T
Abstract:
Proteolysis in close vicinity of tumor cells is a hallmark of cancer invasion and metastasis. We show here that mouse mammary tumor virus-polyoma middle T antigen (PyMT) transgenic mice deficient for the cysteine protease cathepsin B (CTSB) exhibited a significantly delayed onset and reduced growth rate of mammary cancers compared with wild-type PyMT mice. Lung metastasis volumes were significantly reduced in PyMT; ctsb(+/-), an effect that was not further enhanced in PyMT; ctsb(-/-) mice. Furth...     »
Journal title abbreviation:
Cancer Res
Year:
2006
Journal volume:
66
Journal issue:
10
Pages contribution:
5242-50
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-05-4463
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16707449
Print-ISSN:
0008-5472
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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