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Title:

Na+/Ca2+ exchanger overexpression impairs frequency- and ouabain-dependent cell shortening in adult rat cardiomyocytes.

Document type:
Journal Article; Article
Author(s):
Bölck, B; Munch, G; Mackenstein, P; Hellmich, M; Hirsch, I; Reuter, H; Hattebuhr, N; Weig, HJ; Ungerer, M; Brixius, K; Schwinger, RH
Abstract:
The Na(+)/Ca(2+) exchanger (NCX) may influence cardiac function depending on its predominant mode of action, forward mode or reverse mode, during the contraction-relaxation cycle. The intracellular Na(+) concentration ([Na(+)](i)) and the duration of the action potential as well as the level of NCX protein expression regulate the mode of action of NCX. [Na(+)](i) and NCX expression have been reported to be increased in human heart failure. Nevertheless, the consequences of altered NCX expression...     »
Journal title abbreviation:
Am J Physiol Heart Circ Physiol
Year:
2004
Journal volume:
287
Journal issue:
4
Pages contribution:
H1435-45
Language:
eng
Fulltext / DOI:
doi:10.1152/ajpheart.00397.2003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15165985
Print-ISSN:
0363-6135
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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