Ghrelin response to protein and carbohydrate meals in relation to food intake and glycerol levels in obese subjects.

Erdmann, J; Leibl, M; Wagenpfeil, S; Lippl, F; Schusdziarra, V

doi:10.1016/j.regpep.2006.03.003

2006

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Titel:: Ghrelin response to protein and carbohydrate meals in relation to food intake and glycerol levels in obese subjects.
Dokumenttyp:: Journal Article; Article
Autor(en):: Erdmann, J; Leibl, M; Wagenpfeil, S; Lippl, F; Schusdziarra, V
Abstract:: Obese subjects have lower basal and an attenuated decrease of postprandial plasma ghrelin following carbohydrate-rich meals, while the response to protein is unknown. Therefore, plasma ghrelin levels were examined after ingestion of satiating amounts of a protein- or carbohydrate-rich meal in relation to food and energy intake and hunger/satiety ratings in 30 obese subjects followed 240 min later by ad lib sandwiches. Food intake and hunger/satiety ratings were identical while energy intake was significantly greater after bread (861 +/- 62.7 vs. 441 +/- 50.4 kcal, p < 0.001). Second meal food and energy intake were not different. Ghrelin decreased after bread, but increased by 50 pg/ml (p < 0.001) after meat. The corresponding increase of insulin was 55 vs. 9 microU/ml (p < 0.001). Glycerol levels decreased significantly less after the protein meal compared to carbohydrates. After protein glycerol was significantly correlated to the rise of ghrelin but not insulin. These data demonstrate that, in obese subjects, protein has no different satiating effect than carbohydrate despite divergent ghrelin levels. Energy intake corresponds to energy density of the respective food items. Ghrelin response to both meals is qualitatively similar but quantitatively attenuated compared to normal weight subjects. The relationship between ghrelin and glycerol would support recent observations of a possible role of ghrelin in fat metabolism.
Zeitschriftentitel:: Regul Pept
Jahr:: 2006
Band / Volume:: 135
Heft / Issue:: 1-2
Seitenangaben Beitrag:: 23-9
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.regpep.2006.03.003
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/16644032
Print-ISSN:: 0167-0115
TUM Einrichtung:: Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; Institut für Medizinische Statistik und Epidemiologie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik für Ernährungsmedizin (Prof. Hauner)2006

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für KI und Informatik in der Medizin (Prof. Rückert)2006