Borrelia burgdorferi complement regulator-acquiring surface protein 1 of the Lyme disease spirochetes is expressed in humans and induces antibody responses restricted to nondenatured structural determinants.

Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):: Rossmann, E; Kitiratschky, V; Hofmann, H; Kraiczy, P; Simon, MM; Wallich, R
Titel:: Borrelia burgdorferi complement regulator-acquiring surface protein 1 of the Lyme disease spirochetes is expressed in humans and induces antibody responses restricted to nondenatured structural determinants.
Abstract:: Borrelia burgdorferi complement regulator-acquiring surface protein 1 (CRASP-1), the dominant factor H and FHL-1-binding protein of the Lyme disease spirochete B. burgdorferi, is implicated in pathogen persistence and was recently reported to be nonimmunogenic in humans. Here we show that serum samples from Lyme disease patients contain antibodies with exclusive specificity for nondenatured structural determinants of CRASP-1.
Zeitschriftentitel:: Infect Immun
Jahr:: 2006
Band / Volume:: 74
Heft / Issue:: 12
Seitenangaben Beitrag:: 7024-8
Sprache:: eng
Volltext / DOI:: doi:10.1128/IAI.01028-06
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/17000728
Print-ISSN:: 0019-9567
TUM Einrichtung:: Klinik und Poliklinik für Dermatologie und Allergologie
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