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Titel:

Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.

Dokumenttyp:
Journal Article; Article
Autor(en):
Weidinger, S; Illig, T; Baurecht, H; Irvine, AD; Rodriguez, E; Díaz-Lacava, A; Klopp, N; Wagenpfeil, S; Zhao, Y; Liao, H; Lee, SP; Palmer, CN; Jenneck, C; Maintz, L; Hagemann, T; Behrendt, H; Ring, J; Nöthen, MM; McLean, WH; Novak, N
Abstract:
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a strong genetic background. One of the characteristic features of AD and causative factor for the disease is an impaired epidermal skin barrier based on a primary defect of epidermal differentiation. OBJECTIVES: Recently, 2 loss-of-function mutations (R501X and 2282derl4) in the filaggrin gene (FLG) that cause ichthyosis vulgaris, one of the most common inherited skin disorders of keratinization, have been reported t...     »
Zeitschriftentitel:
J Allergy Clin Immunol
Jahr:
2006
Band / Volume:
118
Heft / Issue:
1
Seitenangaben Beitrag:
214-9
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jaci.2006.05.004
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16815158
Print-ISSN:
0091-6749
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie
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