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Titel:

The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.

Dokumenttyp:
Journal Article; Article
Autor(en):
Hofer, A; Berg, D; Asmus, F; Niwar, M; Ransmayr, G; Riemenschneider, M; Bonelli, SB; Steffelbauer, M; Ceballos-Baumann, A; Haussermann, P; Behnke, S; Kruger, R; Prestel, J; Sharma, M; Zimprich, A; Riess, O; Gasser, T
Abstract:
Background: A triplication of the alpha-synuclein gene was found to cause autosomal dominant Lewy body disease in two distinct families. Method: We searched for alterations of alpha-synuclein gene dosage and analysed the entire coding region for point mutations in 54 dementia with Lewy body disease (DLB) and in 103 young onset Parkinson's disease (PD) patients from Central Europe. Results: We could not detect any quantitative alterations in the gene dosage of alpha-synuclein. Mutational screenin...     »
Zeitschriftentitel:
J Neural Transm
Jahr:
2005
Band / Volume:
112
Heft / Issue:
9
Seitenangaben Beitrag:
1249-54
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00702-004-0263-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15622440
Print-ISSN:
0300-9564
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie; Neurologische Klinik und Poliklinik
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