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Document type:
journal article 
Author(s):
Paschen, A; Jing, W; Drexler, I; Klemm, M; Song, M; Müller-Berghaus, J; Nguyen, XD; Osen, W; Stevanovic, S; Sutter, G; Schadendorf, D 
Title:
Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2. 
Abstract:
Tyrosinase-related protein-2 (TRP-2) is a known target antigen of spontaneous cytotoxic T cell responses in melanoma patients. Its frequent expression in metastatic tumors suggests that it might be an ideal candidate antigen for T cell-based immunotherapy. To provide knowledge about TRP-2-derived T cell epitopes useful for immunotherapy we applied a "reverse immunology strategy" based on repeated in vitro peptide stimulation of peripheral blood lymphocytes (PBL) from normal donors with predicted...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2005 
Journal volume:
116 
Journal issue:
Pages contribution:
944-8 
Language:
eng 
Print-ISSN:
0020-7136 
TUM Institution:
Institut für Virologie