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Document type:
journal article 
Author(s):
Quinnan, GV; Yu, XF; Lewis, MG; Zhang, PF; Sutter, G; Silvera, P; Dong, M; Choudhary, A; Sarkis, PT; Bouma, P; Zhang, Z; Montefiori, DC; Vancott, TC; Broder, CC 
Title:
Protection of rhesus monkeys against infection with minimally pathogenic simian-human immunodeficiency virus: correlations with neutralizing antibodies and cytotoxic T cells. 
Abstract:
We studied the capacity of active immunization of rhesus monkeys with HIV-1 envelope protein (Env) to induce primary virus cross-reactive neutralizing antibodies to prevent infection following intravenous challenge with simian-human immunodeficiency virus (SHIV). Monkeys were immunized with the human immunodeficiency type 1 (HIV-1) strain R2 Env. Initially, the Env was expressed in vivo by an alphavirus replicon particle system, and then it was administered as soluble oligomeric gp140. Concurren...    »
 
Journal title abbreviation:
J Virol 
Year:
2005 
Journal volume:
79 
Journal issue:
Pages contribution:
3358-69 
Language:
eng 
Print-ISSN:
0022-538X 
TUM Institution:
Institut für Virologie