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Document type:
journal article 
Author(s):
Staib, C; Kisling, S; Erfle, V; Sutter, G 
Title:
Inactivation of the viral interleukin 1beta receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara. 
Abstract:
Interleukin 1 (IL1) is an important regulator of inflammatory responses and contributes to host immune defence against infection. Vaccinia virus encodes a viral soluble IL1beta receptor (IL1betaR), which modulates the acute-phase host response to infection and might influence the induction of immune responses against virus-associated antigens. Here, modified vaccinia virus Ankara (MVA) mutants defective in IL1betaR production were produced by insertion of selectable marker gene sequences that pr...    »
 
Journal title abbreviation:
J Gen Virol 
Year:
2005 
Journal volume:
86 
Journal issue:
Pt 7 
Pages contribution:
1997-2006 
Language:
eng 
Print-ISSN:
0022-1317 
TUM Institution:
Institut für Virologie