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Titel:

Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells.

Dokumenttyp:
Journal Article; Article
Autor(en):
Greenwood, AD; Horsch, M; Stengel, A; Vorberg, I; Lutzny, G; Maas, E; Schädler, S; Erfle, V; Beckers, J; Schätzl, H; Leib-Mösch, C
Abstract:
The overall impact of prion disease on gene expression is not well characterized. We have carried out a large-scale expression analysis of specific cell types commonly employed in studies of prion disease. Neuroblastoma cells (N2a) and hypothalamic neuronal cells (GT1) can be persistently infected with mouse-adapted scrapie prions, the latter demonstrating cytopathologic effects associated with prion neuropathology. Exploiting a mouse DNA microarray containing approximately 21,000 spotted cDNAs,...     »
Zeitschriftentitel:
J Mol Biol
Jahr:
2005
Band / Volume:
349
Heft / Issue:
3
Seitenangaben Beitrag:
487-500
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jmb.2005.03.076
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15896347
Print-ISSN:
0022-2836
TUM Einrichtung:
Institut für Virologie
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