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Title:

The poxviral scrapin MV-LAP requires a myxoma viral infection context to efficiently downregulate MHC-I molecules.

Document type:
Journal Article
Author(s):
Collin, N; Guérin, JL; Drexler, I; Blanié, S; Gelfi, J; Boullier, S; Foucras, G; Sutter, G; Messud-Petit, F
Abstract:
Downregulation of MHC class I molecules is a strategy developed by some viruses to escape cellular immune responses. Myxoma virus (MV), a poxvirus causing rabbit myxomatosis, encodes MV-LAP that is known to increase MHC-I endocytosis and degradation through a C(4)HC(3) motif critical for an E3 ubiquitin ligase activity. Here, we performed a functional mapping of MV-LAP and showed that not only the C(4)HC(3) motif is necessary for a marked downregulation of MHC-I but also a conserved region in th...     »
Journal title abbreviation:
Virology
Year:
2005
Journal volume:
343
Journal issue:
2
Pages contribution:
171-8
Language:
eng
Fulltext / DOI:
doi:10.1016/j.virol.2005.07.032
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16185739
Print-ISSN:
0042-6822
TUM Institution:
Institut für Virologie
 BibTeX