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Titel:

Charged bipolar suramin derivatives induce aggregation of the prion protein at the cell surface and inhibit PrPSc replication.

Dokumenttyp:
Journal Article; Article
Autor(en):
Nunziante, M; Kehler, C; Maas, E; Kassack, MU; Groschup, M; Schätzl, HM
Abstract:
The conversion of the cellular prion protein (PrPc) into a pathogenic isoform (PrP(Sc)) is one of the underlying events in the pathogenesis of the fatal transmissible spongiform encephalopathies (TSEs). Numerous compounds have been described to inhibit prion replication and PrP(Sc) accumulation in cell culture. Among these, the drug suramin induces aggregation and re-targeting of PrPc to endocytic compartments. Plasma membrane and sites of conversion into PrP(Sc) are thereby bypassed. In the pre...     »
Zeitschriftentitel:
J Cell Sci
Jahr:
2005
Band / Volume:
118
Heft / Issue:
Pt 21
Seitenangaben Beitrag:
4959-73
Sprache:
eng
Volltext / DOI:
doi:10.1242/jcs.02609
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16219680
Print-ISSN:
0021-9533
TUM Einrichtung:
Institut für Virologie
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