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Titel:

Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.

Dokumenttyp:
Journal Article
Autor(en):
Paschen, A; Jing, W; Drexler, I; Klemm, M; Song, M; Müller-Berghaus, J; Nguyen, XD; Osen, W; Stevanovic, S; Sutter, G; Schadendorf, D
Abstract:
Tyrosinase-related protein-2 (TRP-2) is a known target antigen of spontaneous cytotoxic T cell responses in melanoma patients. Its frequent expression in metastatic tumors suggests that it might be an ideal candidate antigen for T cell-based immunotherapy. To provide knowledge about TRP-2-derived T cell epitopes useful for immunotherapy we applied a "reverse immunology strategy" based on repeated in vitro peptide stimulation of peripheral blood lymphocytes (PBL) from normal donors with predicted...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2005
Band / Volume:
116
Heft / Issue:
6
Seitenangaben Beitrag:
944-8
Sprache:
eng
Volltext / DOI:
doi:10.1002/ijc.21132
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15856458
Print-ISSN:
0020-7136
TUM Einrichtung:
Institut für Virologie
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