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- Dokumenttyp:
- Journal Article; Article
- Autor(en):
- Reiniger, IW; Schaller, UC; Haritoglou, C; Hein, R; Bosserhoff, AK; Kampik, A; Mueller, AJ
- Titel:
- "Melanoma inhibitory activity" (MIA): a promising serological tumour marker in metastatic uveal melanoma.
- Abstract:
- PURPOSE: To assess the role of "melanoma inhibitory activity" (MIA) as a potential serum marker for screening and detection of metastatic uveal melanoma. DESIGN: Prospective, clinical study. MATERIAL AND METHODS: Serum samples of 305 patients with uveal melanoma were collected. Serum samples were analysed by a one-step enzyme-linked immunosorbent assay (ELISA) to quantify the MIA serum levels. All patients underwent a standardized echography of the globe to evaluate maximum tumour height and were checked for systemic metastasis of the tumour by liver enzyme tests and ultrasonography of the liver. RESULTS: Twenty patients (6.6%) had proven metastatic disease; eight of them developed it during follow-up. The mean serum concentration of MIA in the 285 patients without metastasis was 6.72 ng/ml, whereas the mean serum concentration of MIA in the 20 patients with metastasis was 13.03 ng/ml (P<0.001). The eight patients who developed metastatic disease during follow-up showed an MIA of 5.92 ng/ml before detection of metastasis and 12.21 ng/ml afterwards (P<0.001). MIA serum levels did neither correlate with the tumour height or to whether local therapy had been applied. CONCLUSION: The elevation of MIA serum levels in patients with metastatic disease from melanoma supports its promising role as a serum marker for monitoring patients with uveal melanoma.
- Zeitschriftentitel:
- Graefes Arch Clin Exp Ophthalmol
- Jahr:
- 2005
- Band / Volume:
- 243
- Heft / Issue:
- 11
- Seitenangaben Beitrag:
- 1161-6
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1007/s00417-005-1171-4
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/15906071
- Print-ISSN:
- 0721-832X
- TUM Einrichtung:
- Klinik und Poliklinik für Dermatologie und Allergologie
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