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Title:

Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults.

Document type:
Journal Article; Article
Author(s):
Weidinger, S; Klopp, N; Wagenpfeil, S; Rümmler, L; Schedel, M; Kabesch, M; Schäfer, T; Darsow, U; Jakob, T; Behrendt, H; Wichmann, HE; Ring, J; Illig, T
Abstract:
BACKGROUND: Several studies have shown linkage of chromosome 12q 13-24 with atopy related phenotypes. Among candidate genes in this region is STAT6 (signal transducer and activator of transcription), which is essential for Th2 cell differentiation, recruitment, and effector function. METHODS: We evaluated six polymorphisms of STAT6 for evidence of associations with serum IgE levels and atopic diseases in a population based cross sectional cohort of 1407 German adults. Genotyping was performed us...     »
Journal title abbreviation:
J Med Genet
Year:
2004
Journal volume:
41
Journal issue:
9
Pages contribution:
658-63
Language:
eng
Fulltext / DOI:
doi:10.1136/jmg.2004.020263
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15342695
Print-ISSN:
0022-2593
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie
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