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Document type:
Journal Article; Article 
Author(s):
Woolhiser, MR; Brockow, K; METCALFE, DD 
Title:
Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a. 
Abstract:
Human mast cells (huMC) increase surface expression of FcgammaRI (CD64) in response to IFNgamma. Subsequent receptor aggregation of FcgammaR1 using CD64-specific F(ab')(2) or antibody directed against FcgammaR1-bound IgG results in cell activation. Human mast cells may be observed degranulating in inflammation associated with autoimmune disease and where IFNgamma is produced. We sought to determine if human mast cells cultured in IFNgamma would degranulate in response to aggregated IgG, what med...    »
 
Journal title abbreviation:
Clin Immunol 
Year:
2004 
Journal volume:
110 
Journal issue:
Pages contribution:
172-80 
Language:
eng 
Print-ISSN:
1521-6616 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie