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Titel:

Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation.

Dokumenttyp:
Journal Article; Article
Autor(en):
Moosmang, S; Schulla, V; Welling, A; Feil, R; Feil, S; Wegener, JW; Hofmann, F; Klugbauer, N
Abstract:
Blood pressure is regulated by a number of key molecules involving G-protein-coupled receptors, ion channels and monomeric small G-proteins. The relative contribution of these different signaling pathways to blood pressure regulation remains to be determined. Tamoxifen-induced, smooth muscle-specific inactivation of the L-type Cav1.2 Ca2+ channel gene in mice (SMAKO) reduced mean arterial blood pressure (MAP) in awake, freely moving animals from 120 +/- 4.5 to 87 +/- 8 mmHg. Phenylephrine (PE)-...     »
Zeitschriftentitel:
EMBO J
Jahr:
2003
Band / Volume:
22
Heft / Issue:
22
Seitenangaben Beitrag:
6027-34
Sprache:
eng
Volltext / DOI:
doi:10.1093/emboj/cdg583
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14609949
Print-ISSN:
0261-4189
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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