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Title:

Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2.

Document type:
Journal Article; Article
Author(s):
Ludwig, A; Budde, T; Stieber, J; Moosmang, S; Wahl, C; Holthoff, K; Langebartels, A; Wotjak, C; Munsch, T; Zong, X; Feil, S; Feil, R; Lancel, M; Chien, KR; Konnerth, A; Pape, HC; Biel, M; Hofmann, F
Abstract:
Hyperpolarization-activated cation (HCN) channels are believed to be involved in the generation of cardiac pacemaker depolarizations as well as in the control of neuronal excitability and plasticity. The contributions of the four individual HCN channel isoforms (HCN1-4) to these diverse functions are not known. Here we show that HCN2-deficient mice exhibit spontaneous absence seizures. The thalamocortical relay neurons of these mice displayed a near complete loss of the HCN current, resulting in...     »
Journal title abbreviation:
EMBO J
Year:
2003
Journal volume:
22
Journal issue:
2
Pages contribution:
216-24
Language:
eng
Fulltext / DOI:
doi:10.1093/emboj/cdg032
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12514127
Print-ISSN:
0261-4189
TUM Institution:
Institut für Neurowissenschaften; Institut für Pharmakologie und Toxikologie
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