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Titel:

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

Dokumenttyp:
Journal Article; Article
Autor(en):
Xu, M; Welling, A; Paparisto, S; Hofmann, F; Klugbauer, N
Abstract:
Voltage-gated calcium (Ca2+) channels play a key role in the control of heart contraction and are essential for normal heart development. The Cav1.2 L-type calcium channel is the predominant isoform in cardiomyocytes and is essential for excitation-contraction coupling. Although the inactivation of the Cav1.2 gene caused embryonic lethality before embryonic day E14.5, hearts were contracting before E14 depending on a dihydropyridine-sensitive calcium influx. We analyzed the consequences of the d...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2003
Band / Volume:
278
Heft / Issue:
42
Seitenangaben Beitrag:
40837-41
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M307598200
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12900400
Print-ISSN:
0021-9258
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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