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Title:

Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice.

Document type:
Journal Article; Review; Review
Author(s):
Feil, R; Lohmann, SM; de Jonge, H; Walter, U; Hofmann, F
Abstract:
Signaling cascades initiated by nitric oxide (NO) and natriuretic peptides (NPs) play an important role in the maintenance of cardiovascular homeostasis. It is currently accepted that many effects of these endogenous signaling molecules are mediated via stimulation of guanylyl cyclases and intracellular production of the second messenger cGMP. Indeed, cGMP-elevating drugs like glyceryl trinitrate have been used for more than 100 years to treat cardiovascular diseases. However, the molecular mech...     »
Journal title abbreviation:
Circ Res
Year:
2003
Journal volume:
93
Journal issue:
10
Pages contribution:
907-16
Language:
eng
Fulltext / DOI:
doi:10.1161/01.RES.0000100390.68771.CC
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14615494
Print-ISSN:
0009-7330
TUM Institution:
Institut für Pharmakologie und Toxikologie
 BibTeX