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Title:

Extracellular Ca2+ modulates the effects of protons on gating and conduction properties of the T-type Ca2+ channel alpha1G (CaV3.1).

Document type:
Journal Article; Article
Author(s):
Talavera, K; Janssens, A; Klugbauer, N; Droogmans, G; Nilius, B
Abstract:
Since Ca2+ is a major competitor of protons for the modulation of high voltage-activated Ca2+ channels, we have studied the modulation by extracellular Ca2+ of the effects of proton on the T-type Ca2+ channel alpha1G (CaV3.1) expressed in HEK293 cells. At 2 mM extracellular Ca2+ concentration, extracellular acidification in the pH range from 9.1 to 6.2 induced a positive shift of the activation curve and increased its slope factor. Both effects were significantly reduced if the concentration was...     »
Journal title abbreviation:
Phys Rev E Stat Nonlin Soft Matter Phys
Year:
2003
Journal volume:
121
Journal issue:
6
Pages contribution:
511-28
Language:
eng
Fulltext / DOI:
doi:10.1085/jgp.200308793
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12743167
Print-ISSN:
1539-3755
TUM Institution:
Institut für Pharmakologie und Toxikologie
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