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Title:

Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I.

Document type:
Journal Article; Article
Author(s):
Feil, R; Hartmann, J; Luo, C; Wolfsgruber, W; Schilling, K; Feil, S; Barski, JJ; Meyer, M; Konnerth, A; De Zeeuw, CI; Hofmann, F
Abstract:
The molecular basis for cerebellar plasticity and motor learning remains controversial. Cerebellar Purkinje cells (PCs) contain a high concentration of cGMP-dependent protein kinase type I (cGKI). To investigate the function of cGKI in long-term depression (LTD) and cerebellar learning, we have generated conditional knockout mice lacking cGKI selectively in PCs. These cGKI mutants had a normal cerebellar morphology and intact synaptic calcium signaling, but strongly reduced LTD. Interestingly, n...     »
Journal title abbreviation:
J Cell Biol
Year:
2003
Journal volume:
163
Journal issue:
2
Pages contribution:
295-302
Language:
eng
Fulltext / DOI:
doi:10.1083/jcb.200306148
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14568994
Print-ISSN:
0021-9525
TUM Institution:
Institut für Neurowissenschaften; Institut für Pharmakologie und Toxikologie
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