User: Guest  Login
Less Searchfields
Simple search
Title:

Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Fischer, SF; Ludwig, H; Holzapfel, J; Kvansakul, M; Chen, L; Huang, DC; Sutter, G; Knese, M; Häcker, G
Abstract:
Infection with viruses often protects the infected cell against external stimuli to apoptosis. Here we explore the balance of apoptosis induction and inhibition for infection with the modified vaccinia virus Ankara (MVA), using two MVA mutants with experimentally introduced deletions. Deletion of the E3L-gene from MVA transformed the virus from an inhibitor to an inducer of apoptosis. Noxa-deficient mouse embryonic fibroblasts (MEF) were resistant to MVA-DeltaE3L-induced apoptosis. When the gene...     »
Journal title abbreviation:
Cell Death Differ
Year:
2006
Journal volume:
13
Journal issue:
1
Pages contribution:
109-18
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.cdd.4401718
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16003387
Print-ISSN:
1350-9047
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX