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Titel:

Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Fischer, SF; Ludwig, H; Holzapfel, J; Kvansakul, M; Chen, L; Huang, DC; Sutter, G; Knese, M; Häcker, G
Abstract:
Infection with viruses often protects the infected cell against external stimuli to apoptosis. Here we explore the balance of apoptosis induction and inhibition for infection with the modified vaccinia virus Ankara (MVA), using two MVA mutants with experimentally introduced deletions. Deletion of the E3L-gene from MVA transformed the virus from an inhibitor to an inducer of apoptosis. Noxa-deficient mouse embryonic fibroblasts (MEF) were resistant to MVA-DeltaE3L-induced apoptosis. When the gene...     »
Zeitschriftentitel:
Cell Death Differ
Jahr:
2006
Band / Volume:
13
Heft / Issue:
1
Seitenangaben Beitrag:
109-18
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.cdd.4401718
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16003387
Print-ISSN:
1350-9047
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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