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Title:

Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis.

Document type:
Journal Article
Author(s):
Weighardt, H; Mages, J; Jusek, G; Kaiser-Moore, S; Lang, R; Holzmann, B
Abstract:
Sepsis leads to the rapid induction of proinflammatory signaling cascades by activation of the innate immune system through Toll-like receptors (TLR). To characterize the role of TLR signaling through MyD88 for sepsis-induced transcriptional activation, we investigated gene expression during polymicrobial septic peritonitis by microarray analysis. Comparison of gene expression profiles for spleens and livers from septic wild-type and MyD88-deficient mice revealed striking organ-specific differen...     »
Journal title abbreviation:
Infect Immun
Year:
2006
Journal volume:
74
Journal issue:
6
Pages contribution:
3618-32
Language:
eng
Fulltext / DOI:
doi:10.1128/IAI.01681-05
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16714594
Print-ISSN:
0019-9567
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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