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Title:

All is not Toll: new pathways in DNA recognition.

Document type:
Journal Article; Review; Review
Author(s):
Wagner, H; Bauer, S
Abstract:
Immunological defense depends on the ability of the innate immune system to recognize invading microbes as foreign and thus eliminate them. The Toll-like receptors (TLRs) help detect foreign invaders by sensing various pathogen-associated molecules, including microbial RNA and DNA. At present, it is unclear whether and how the immune system distinguishes between microbial and self nucleic acids, as host-derived RNA and DNA also stimulate TLRs. In addition, recent studies have revealed the existe...     »
Journal title abbreviation:
J Exp Med
Year:
2006
Journal volume:
203
Journal issue:
2
Pages contribution:
265-8
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20052191
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16446382
Print-ISSN:
0022-1007
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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