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Title:

Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Verbeke, P; Welter-Stahl, L; Ying, S; Hansen, J; Häcker, G; Darville, T; Ojcius, DM
Abstract:
Chlamydiae replicate intracellularly in a vacuole called an inclusion. Chlamydial-infected host cells are protected from mitochondrion-dependent apoptosis, partly due to degradation of BH3-only proteins. The host-cell adapter protein 14-3-3beta can interact with host-cell apoptotic signaling pathways in a phosphorylation-dependent manner. In Chlamydia trachomatis-infected cells, 14-3-3beta co-localizes to the inclusion via direct interaction with a C. trachomatis-encoded inclusion membrane prote...     »
Journal title abbreviation:
PLoS Pathog
Year:
2006
Journal volume:
2
Journal issue:
5
Pages contribution:
e45
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.ppat.0020045
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16710454
Print-ISSN:
1553-7366
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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