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Title:

Genetically determined susceptibility to tuberculosis in mice causally involves accelerated and enhanced recruitment of granulocytes.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Keller, C; Hoffmann, R; Lang, R; Brandau, S; Hermann, C; Ehlers, S
Abstract:
Classical twin studies and recent linkage analyses of African populations have revealed a potential involvement of host genetic factors in susceptibility or resistance to Mycobacterium tuberculosis infection. In order to identify the candidate genes involved and test their causal implication, we capitalized on the mouse model of tuberculosis, since inbred mouse strains also differ substantially in their susceptibility to infection. Two susceptible and two resistant mouse strains were aerogenical...     »
Journal title abbreviation:
Infect Immun
Year:
2006
Journal volume:
74
Journal issue:
7
Pages contribution:
4295-309
Language:
eng
Fulltext / DOI:
doi:10.1128/IAI.00057-06
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16790804
Print-ISSN:
0019-9567
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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