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Titel:

TLR-dependent Bim phosphorylation in macrophages is mediated by ERK and is connected to proteasomal degradation of the protein.

Dokumenttyp:
Journal Article
Autor(en):
Häcker, G; Suttner, K; Harada, H; Kirschnek, S
Abstract:
The pro-apoptotic Bcl-2 homology domain 3-only protein Bim has been shown to play an important role in immune cell homeostasis and various forms of apoptosis in the immune system. Bim is expressed in most immune cells, and regulation of Bim activity can occur on both transcriptional and post-translational levels. Toll-like receptor (TLR) stimulation has previously been shown to increase Bim expression and to cause Bim phosphorylation in the absence of apoptosis in mouse macrophages. Here we iden...     »
Zeitschriftentitel:
Int Immunol
Jahr:
2006
Band / Volume:
18
Heft / Issue:
12
Seitenangaben Beitrag:
1749-57
Sprache:
eng
Volltext / DOI:
doi:10.1093/intimm/dxl109
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17105963
Print-ISSN:
0953-8178
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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