Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
You, H; Pellegrini, M; Tsuchihara, K; Yamamoto, K; Häcker, G; Erlacher, M; Villunger, A; Mak, TW
Abstract:
Puma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, Puma is induced in a p53-dependent manner. However, the transcription factor driving Puma up-regulation in response to p53-independent apoptotic stimuli has yet to be identified. Here, we show that FOXO3a up-regulates Puma expression in response to cytokine or growth factor deprivation. Importantly, dysregulated Akt signaling in lymphoid cells attenuated Puma induction upon cytokin...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2006
Band / Volume:
203
Heft / Issue:
7
Seitenangaben Beitrag:
1657-63
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20060353
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16801400
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX