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Titel:

Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Verbeke, P; Welter-Stahl, L; Ying, S; Hansen, J; Häcker, G; Darville, T; Ojcius, DM
Abstract:
Chlamydiae replicate intracellularly in a vacuole called an inclusion. Chlamydial-infected host cells are protected from mitochondrion-dependent apoptosis, partly due to degradation of BH3-only proteins. The host-cell adapter protein 14-3-3beta can interact with host-cell apoptotic signaling pathways in a phosphorylation-dependent manner. In Chlamydia trachomatis-infected cells, 14-3-3beta co-localizes to the inclusion via direct interaction with a C. trachomatis-encoded inclusion membrane prote...     »
Zeitschriftentitel:
PLoS Pathog
Jahr:
2006
Band / Volume:
2
Heft / Issue:
5
Seitenangaben Beitrag:
e45
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.ppat.0020045
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16710454
Print-ISSN:
1553-7366
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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