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Title:

Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells.

Document type:
Journal Article; Research Support, N.I.H., Extramural
Author(s):
Grzywacz, B; Kataria, N; Sikora, M; Oostendorp, RA; Dzierzak, EA; Blazar, BR; Miller, JS; Verneris, MR
Abstract:
The stages of human natural killer (NK) cell differentiation are not well established. Culturing CD34(+) progenitors with interleukin 7 (IL-7), IL-15, stem cell factor (SCF), FLT-3L, and murine fetal liver cell line (EL08.1D2), we identified 2 nonoverlapping subsets of differentiating CD56(+) cells based on CD117 and CD94 (CD117(high)CD94(-) and CD117(low/-)CD94(+) cells). Both populations expressed CD161 and NKp44, but differed with respect to NKp30, NKp46, NKG2A, NKG2C, NKG2D, CD8, CD16, and K...     »
Journal title abbreviation:
Blood
Year:
2006
Journal volume:
108
Journal issue:
12
Pages contribution:
3824-33
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2006-04-020198
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16902150
Print-ISSN:
0006-4971
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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