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Titel:

The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells.

Dokumenttyp:
Journal Article
Autor(en):
Borsutzky, S; Kretschmer, K; Becker, PD; Mühlradt, PF; Kirschning, CJ; Weiss, S; Guzman, CA
Abstract:
The macrophage-activating lipopeptide-2 (MALP-2) is an agonist of the TLR heterodimer 2/6, which exhibits potent activity as mucosal adjuvant, promoting strong humoral and cellular responses. Although B cells expressing TLR2/6 are potential targets, very little is known about the effect of MALP-2 on B cells. Studies were performed using total spleen cells or purified B cells from WT mice or animals deficient in TLR2, T cells, B cells, or specific subpopulations of B cells. They demonstrated that...     »
Zeitschriftentitel:
J Immunol
Jahr:
2005
Band / Volume:
174
Heft / Issue:
10
Seitenangaben Beitrag:
6308-13
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15879130
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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