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Title:

Engagement of Toll-like receptors by mycoplasmal superantigen: downregulation of TLR2 by MAM/TLR4 interaction.

Document type:
Journal Article
Author(s):
Mu, HH; Pennock, ND; Humphreys, J; Kirschning, CJ; Cole, BC
Abstract:
Mycoplasma arthritidis mitogen (MAM) is a superantigen (SAg) from M. arthritidis, an agent of murine toxic shock syndrome and arthritis. We previously demonstrated that C3H/HeJ and C3H/HeSnJ mice that differ in expression of TLR4 differed in immune reactivity to MAM. We show here that MAM directly interacts with TLR2 and TLR4 by using monoclonal antibodies to TLR2 and TLR4 which inhibit cytokine responses of THP-1 cells to MAM. Also, using macrophages from C3H substrains and TLR2-deficient mice,...     »
Journal title abbreviation:
Cell Microbiol
Year:
2005
Journal volume:
7
Journal issue:
6
Pages contribution:
789-97
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1462-5822.2005.00511.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15888082
Print-ISSN:
1462-5814
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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