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Title:

Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice.

Document type:
Journal Article
Author(s):
De Lema, GP; Maier, H; Franz, TJ; Escribese, M; Chilla, S; Segerer, S; Camarasa, N; Schmid, H; Banas, B; Kalaydjiev, S; Busch, DH; Pfeffer, K; Mampaso, F; Schlöndorff, D; Luckow, B
Abstract:
MRL/MpJ-Fas(lpr)/J (MRL/lpr) mice represent a well-established mouse model of human systemic lupus erythematosus. MRL/lpr mice homozygous for the spontaneous lymphoproliferation mutation (lpr) are characterized by systemic autoimmunity, massive lymphadenopathy associated with proliferation of aberrant T cells, splenomegaly, hypergammaglobulinemia, arthritis, and fatal immune complex-mediated glomerulonephritis. It was reported previously that steady-state mRNA levels for the chemokine (C-C motif...     »
Journal title abbreviation:
J Am Soc Nephrol
Year:
2005
Journal volume:
16
Journal issue:
12
Pages contribution:
3592-601
Language:
eng
Fulltext / DOI:
doi:10.1681/ASN.2005040426
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16267157
Print-ISSN:
1046-6673
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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