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Title:

Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis.

Document type:
Journal Article
Author(s):
Ying, S; Seiffert, BM; Häcker, G; Fischer, SF
Abstract:
Chlamydiae are obligate intracellular bacteria that can inhibit apoptosis of their host cell. As shown recently, this inhibition is in part explained by the proteolytic degradation of the proapoptotic Bcl-2 family members (BH3-only proteins) Bim, Puma, and Bad upon chlamydial infection. In this study, we further explore this antiapoptotic mechanism. In cells infected with a Chlamydia trachomatis L2 strain, Bim, Puma, and Bad were degraded with similar kinetics, and the degradation of all three w...     »
Journal title abbreviation:
Infect Immun
Year:
2005
Journal volume:
73
Journal issue:
3
Pages contribution:
1399-403
Language:
eng
Fulltext / DOI:
doi:10.1128/IAI.73.3.1399-1403.2005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15731037
Print-ISSN:
0019-9567
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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