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Title:

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

Document type:
Journal Article
Author(s):
Vollmer, J; Tluk, S; Schmitz, C; Hamm, S; Jurk, M; Forsbach, A; Akira, S; Kelly, KM; Reeves, WH; Bauer, S; Krieg, AM
Abstract:
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies to certain cellular macromolecules, such as the small nuclear ribonucleoprotein particles (snRNPs), which had been considered to be passive targets of the autoimmune response. SLE is also characterized by the increased expression of type I interferon (IFN), which appears to be associated with the development and severity of disease. Here, we show that specific, highly conserved RNA seque...     »
Journal title abbreviation:
J Exp Med
Year:
2005
Journal volume:
202
Journal issue:
11
Pages contribution:
1575-85
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20051696
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16330816
Print-ISSN:
0022-1007
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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