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Titel:

NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145.

Dokumenttyp:
Journal Article
Autor(en):
Krmpotic, A; Hasan, M; Loewendorf, A; Saulig, T; Halenius, A; Lenac, T; Polic, B; Bubic, I; Kriegeskorte, A; Pernjak-Pugel, E; Messerle, M; Hengel, H; Busch, DH; Koszinowski, UH; Jonjic, S
Abstract:
The NK cell-activating receptor NKG2D interacts with three different cellular ligands, all of which are regulated by mouse cytomegalovirus (MCMV). We set out to define the viral gene product regulating murine UL16-binding protein-like transcript (MULT)-1, a newly described NKG2D ligand. We show that MCMV infection strongly induces MULT-1 gene expression, but surface expression of this glycoprotein is nevertheless completely abolished by the virus. Screening a panel of MCMV deletion mutants defin...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2005
Band / Volume:
201
Heft / Issue:
2
Seitenangaben Beitrag:
211-20
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20041617
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15642742
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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