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Titel:

Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer.

Dokumenttyp:
Journal Article
Autor(en):
Mangold, E; Pagenstecher, C; Friedl, W; Mathiak, M; Buettner, R; Engel, C; Loeffler, M; Holinski-Feder, E; Müller-Koch, Y; Keller, G; Schackert, HK; Krüger, S; Goecke, T; Moeslein, G; Kloor, M; Gebert, J; Kunstmann, E; Schulmann, K; Rüschoff, J; Propping, P
Abstract:
Mutations in DNA MMR genes, mainly MSH2 and MLH1, account for the majority of HNPCC, an autosomal dominant predisposition to colorectal cancer and other malignancies. The evaluation of many questions regarding HNPCC requires clinically and genetically well-characterized HNPCC patient cohorts of reasonable size. One main focus of this multicenter study is the evaluation of the mutation spectrum and mutation frequencies in a large HNPCC cohort in Germany; 1,721 unrelated patients, mainly of Germa...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2005
Band / Volume:
116
Heft / Issue:
5
Seitenangaben Beitrag:
692-702
Sprache:
eng
Volltext / DOI:
doi:10.1002/ijc.20863
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15849733
Print-ISSN:
0020-7136
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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