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Titel:

Gene expression profiling of Lewy body-bearing neurons in Parkinson's disease.

Dokumenttyp:
Journal Article
Autor(en):
Lu, L; Neff, F; Alvarez-Fischer, D; Henze, C; Xie, Y; Oertel, WH; Schlegel, J; Hartmann, A
Abstract:
Lewy bodies (LB) are a pathological hallmark of Parkinson's disease (PD). Whether LBs are neuroprotective, cytotoxic, or an age-related epiphenomenon is still debated. In the present study, the genetic fingerprints of mesencephalic dopaminergic (DA) neurons containing LBs versus mesencephalic DA neurons not containing LBs were compared in five PD patients. Total RNA from single neurons of both neuronal subpopulations was obtained by immuno-laser capture microdissection. Subsequently, RNA arbitra...     »
Zeitschriftentitel:
Exp Neurol
Jahr:
2005
Band / Volume:
195
Heft / Issue:
1
Seitenangaben Beitrag:
27-39
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.expneurol.2005.04.011
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15944136
Print-ISSN:
0014-4886
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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