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Title:

Gene expression profiling of Lewy body-bearing neurons in Parkinson's disease.

Document type:
Journal Article
Author(s):
Lu, L; Neff, F; Alvarez-Fischer, D; Henze, C; Xie, Y; Oertel, WH; Schlegel, J; Hartmann, A
Abstract:
Lewy bodies (LB) are a pathological hallmark of Parkinson's disease (PD). Whether LBs are neuroprotective, cytotoxic, or an age-related epiphenomenon is still debated. In the present study, the genetic fingerprints of mesencephalic dopaminergic (DA) neurons containing LBs versus mesencephalic DA neurons not containing LBs were compared in five PD patients. Total RNA from single neurons of both neuronal subpopulations was obtained by immuno-laser capture microdissection. Subsequently, RNA arbitra...     »
Journal title abbreviation:
Exp Neurol
Year:
2005
Journal volume:
195
Journal issue:
1
Pages contribution:
27-39
Language:
eng
Fulltext / DOI:
doi:10.1016/j.expneurol.2005.04.011
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15944136
Print-ISSN:
0014-4886
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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