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Title:

Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer.

Document type:
Journal Article
Author(s):
Mangold, E; Pagenstecher, C; Friedl, W; Mathiak, M; Buettner, R; Engel, C; Loeffler, M; Holinski-Feder, E; Müller-Koch, Y; Keller, G; Schackert, HK; Krüger, S; Goecke, T; Moeslein, G; Kloor, M; Gebert, J; Kunstmann, E; Schulmann, K; Rüschoff, J; Propping, P
Abstract:
Mutations in DNA MMR genes, mainly MSH2 and MLH1, account for the majority of HNPCC, an autosomal dominant predisposition to colorectal cancer and other malignancies. The evaluation of many questions regarding HNPCC requires clinically and genetically well-characterized HNPCC patient cohorts of reasonable size. One main focus of this multicenter study is the evaluation of the mutation spectrum and mutation frequencies in a large HNPCC cohort in Germany; 1,721 unrelated patients, mainly of Germa...     »
Journal title abbreviation:
Int J Cancer
Year:
2005
Journal volume:
116
Journal issue:
5
Pages contribution:
692-702
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.20863
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15849733
Print-ISSN:
0020-7136
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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