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Title:

Expression of p53 and p21 in Primary Glioblastomas.

Document type:
Journal Article
Author(s):
Gross, MW; Kraus, A; Nashwan, K; Mennel, HD; Engenhart-Cabillic, R; Schlegel, J
Abstract:
BACKGROUND AND PURPOSE: : Primary glioblastomas (GBMs) are highly radioresistant, and in contrast to secondary GBMs, they bear wild-type (wt) p53 protein, which is stabilized in a proportion of these tumors. Therefore, it was investigated in vivo whether p53 expression has prognostic value in patients undergoing radiochemotherapy. Additionally, the authors tried to identify, in vitro, subgroups of primary GBM with different susceptibilities to irradiation, on the basis of their p53 and p21 respo...     »
Journal title abbreviation:
Strahlenther Onkol
Year:
2005
Journal volume:
181
Journal issue:
3
Pages contribution:
164-171
Language:
eng
Fulltext / DOI:
doi:10.1007/s00066-005-1304-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15756520
Print-ISSN:
0179-7158
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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