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Title:

Ex vivo expanded dendritic cells home to T-cell zones of lymphoid organs and survive in vivo after allogeneic bone marrow transplantation.

Document type:
Journal Article
Author(s):
Schimmelpfennig, CH; Schulz, S; Arber, C; Baker, J; Tarner, I; McBride, J; Contag, CH; Negrin, RS
Abstract:
Little is known about adoptive transfer of allogeneic ex vivo expanded dendritic cells (eDCs). We investigated the trafficking pattern of eDCs in mice after allogeneic bone marrow transplantation by using bioluminescence imaging. eDCs were expanded from bone marrow precursors in the presence of GM-CSF, interleukin-4, and Flt3L and retrovirally transduced to express luciferase (luc) and green fluorescence protein (gfp). Flow cytometry showed polyclonal DC populations after expansion that consiste...     »
Journal title abbreviation:
Am J Pathol
Year:
2005
Journal volume:
167
Journal issue:
5
Pages contribution:
1321-31
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16251416
Print-ISSN:
0002-9440
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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