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Title:

Low BAX protein expression correlates with disease recurrence in preoperatively irradiated rectal carcinoma.

Document type:
Journal Article
Author(s):
Nehls, O; Okech, T; Hsieh, CJ; Sarbia, M; Borchard, F; Gruenagel, HH; Gaco, V; Porschen, R; Gregor, M; Klump, B
Abstract:
PURPOSE: To determine the prognostic impact of BAX in correlation to its upstream effector p53 as well as clinicopathologic variables and patient outcome in preoperatively irradiated rectal carcinoma. METHODS AND MATERIALS: We investigated 92 rectal carcinoma patients treated by preoperative radiotherapy to a total dose of 30 Gy followed by surgery. Median follow-up was 71 months. Immunohistochemistry was performed on paraffin sections of pretreatment biopsy samples for BAX protein. Also, we con...     »
Journal title abbreviation:
Int J Radiat Oncol Biol Phys
Year:
2005
Journal volume:
61
Journal issue:
1
Pages contribution:
85-91
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ijrobp.2004.05.023
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15629598
Print-ISSN:
0360-3016
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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