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Title:

Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer.

Document type:
Journal Article
Author(s):
Abraham, BK; Justenhoven, C; Pesch, B; Harth, V; Weirich, G; Baisch, C; Rabstein, S; Ko, YD; Bruning, T; Fischer, HP; Haas, S; Brod, S; Oberkanins, C; Hamann, U; Brauch, H
Abstract:
Iron overload has been noticed as a feature of human breast cancer. Cellular iron uptake is regulated by the hemochromatosis and transferrin receptor system, mutations of which cause the iron storage disease hereditary hemochromatosis. To understand the role of hemochromatosis and transferrin receptor system mutations in breast cancer, we analyzed 19 sequence variations at HFE, TFR1, TFR2, and FPN1 and compared genotype frequencies between cases and controls in a German population. There were 68...     »
Journal title abbreviation:
Cancer Epidemiol Biomarkers Prev
Year:
2005
Journal volume:
14
Journal issue:
5
Pages contribution:
1102-7
Language:
eng
Fulltext / DOI:
doi:10.1158/1055-9965.EPI-05-0013
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15894659
Print-ISSN:
1055-9965
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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