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Titel:

The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms.

Dokumenttyp:
Journal Article
Autor(en):
Hapfelmeier, S; Stecher, B; Barthel, M; Kremer, M; Müller, AJ; Heikenwalder, M; Stallmach, T; Hensel, M; Pfeffer, K; Akira, S; Hardt, WD
Abstract:
Salmonella typhimurium can colonize the gut, invade intestinal tissues, and cause enterocolitis. In vitro studies suggest different mechanisms leading to mucosal inflammation, including 1) direct modulation of proinflammatory signaling by bacterial type III effector proteins and 2) disruption or penetration of the intestinal epithelium so that penetrating bacteria or bacterial products can trigger innate immunity (i.e., TLR signaling). We studied these mechanisms in vivo using streptomycin-pretr...     »
Zeitschriftentitel:
J Immunol
Jahr:
2005
Band / Volume:
174
Heft / Issue:
3
Seitenangaben Beitrag:
1675-85
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15661931
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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