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Title:

Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.

Document type:
Journal Article
Author(s):
Nilsson, JA; Keller, UB; Baudino, TA; Yang, C; Norton, S; Old, JA; Nilsson, LM; Neale, G; Kramer, DL; Porter, CW; Cleveland, JL
Abstract:
Checkpoints that control Myc-mediated proliferation and apoptosis are bypassed during tumorigenesis. Genes encoding polyamine biosynthetic enzymes are overexpressed in B cells from E mu-Myc transgenic mice. Here, we report that disabling one of these Myc targets, Ornithine decarboxylase (Odc), abolishes Myc-induced suppression of the Cdk inhibitors p21(Cip1) and p27(Kip1), thereby impairing Myc's proliferative, but not apoptotic, response. Moreover, lymphoma development was markedly delayed in E...     »
Journal title abbreviation:
Cancer Cell
Year:
2005
Journal volume:
7
Journal issue:
5
Pages contribution:
433-44
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ccr.2005.03.036
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15894264
Print-ISSN:
1535-6108
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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